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We reported that chow-fed, adult-onset, hepatocyte-specific, GH receptor knockdown aHepGHRkd mice rapidly within 7 days develop steatosis associated with increased hepatic de novo lipogenesis DNL , independent of changes in systemic metabolic function. In this study, we report that 6 months after induction of aHepGHRkd early signs of NASH develop, which include hepatocyte ballooning, inflammation, signs of mild fibrosis, and elevated plasma alanine aminotransferase.
These changes occur in the presence of enhanced systemic lipid utilization, without evidence of white adipose tissue lipolysis, indicating that the liver injury that develops after aHepGHRkd is due to hepatocyte-specific loss of GH signaling and not due to secondary defects in systemic metabolic function.
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Endocrinology , Volume , Issue 11, November , Pages —, https: You do not currently have access to this article. You could not be signed in. Sign In Forgot password? Don't have an account? Endocrine Society members Sign in via society site. Sign in via your Institution Sign in. Purchase Subscription prices and ordering Short-term Access To purchase short term access, please sign in to your Oxford Academic account above.